Body mass index during maintenance therapy and relapse risk in children with acute lymphoblastic leukemia: A Children's Oncology Group report.

ABSTRACT:

Background

Obesity at diagnosis of childhood acute lymphoblastic leukemia (ALL) is associated with greater risk of relapse; whether this association extends to obesity during maintenance is unstudied.

Methods

This study used data from AALL03N1 to calculate median body mass index (BMI) for 676 children over 6 consecutive months during maintenance therapy; BMI percentile (BMI%ile) were operationalized as normal/underweight (<85%ile), overweight/obese (85%-98%ile), and extreme obesity (≥99%ile). Hazard of relapse was estimated using multivariable proportional subdistributional hazards regression after adjusting for all relevant demographic and clinical predictors.

Results

Median age at study enrollment was 6 years and median length of follow-up was 7.9 years. Overall, 43

SUBMITTER: Wadhwa A 

PROVIDER: S-EPMC10173700 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature