Intravenous thrombolysis versus antiplatelet therapy in minor stroke patients with large vessel occlusion.

ABSTRACT:

Aim

Our study aimed to explore the effectiveness and safety of intravenous t-PA compared with dual antiplatelet therapy (DAPT) and aspirin alone for minor stroke with National Institutes of Health Stroke Scale (NIHSS) score ≤5 and large vessel occlusion (LVO).

Methods

Patients with minor stroke harboring LVO within 4.5-h time window were included from the Third China National Stroke Registry (CNSR-III) between August 2015 and March 2018 in China. Clinical outcomes including modified Rankin scale (mRS) score, recurrent stroke, and all-cause mortality at 90 days and 36-h symptomatic intracerebral hemorrhage (sICH) were collected. Multivariable logistic regression models and propensity score matching analyses were used to determine the association between treatment groups and c

SUBMITTER: Duan C 

PROVIDER: S-EPMC10173711 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature