Functional and structural alterations of dorsal attention network in preclinical and early-stage Alzheimer's disease.

ABSTRACT:

Objectives

Subjective cognitive decline (SCD) and amnestic mild cognitive impairment (aMCI) are known as the preclinical and early stage of Alzheimer's disease (AD). The dorsal attention network (DAN) is mainly responsible for the "top-down" attention process. However, previous studies mainly focused on single functional modality and limited structure. This study aimed to investigate the multimodal alterations of DAN in SCD and aMCI to assess their diagnostic value in preclinical and early-stage AD.

Methods

Resting-state functional magnetic resonance imaging (MRI) was carried out to measure the fractional amplitude of low-frequency fluctuation (fALFF), regional homogeneity (ReHo), and functional connectivity (FC). Structural MRI was used to calculate the gray matter volume (

SUBMITTER: Wu H 

PROVIDER: S-EPMC10173716 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature