β-Glucan attenuates cognitive impairment of APP/PS1 mice via regulating intestinal flora and its metabolites.

ABSTRACT:

Background

The intestinal flora has been shown to be involved in the progression of Alzheimer's disease (AD) and can be improved by β-glucan, a polysaccharide derived from Saccharomyces cerevisiae, which affects cognitive function through the intestinal flora. However, it is not known if this effect of β-glucan is involved in AD.

Method

This study used behavioral testing to measure cognitive function. After that, high-throughput 16 S rRNA gene sequencing and GC-MS were used to analyze the intestinal microbiota and metabolite SCFAs of AD model mice, and further explore the relationship between intestinal flora and neuroinflammation. Finally, the expressions of inflammatory factors in the mouse brain were detected by Western blot and Elisa methods.

Results

We found that

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC10173722 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature