Comparison of cat and human calcium oxalate monohydrate kidney stone matrix proteomes.

ABSTRACT: Despite its critical nature, the role of matrix in calcium oxalate stone formation is poorly understood. The wide diversity of proteins comprising matrix has contributed to the ambiguity. This study compares the protein distributions measured by mass spectrometry in human calcium oxalate stone matrix to that observed in cat stone matrix, because cats share many clinical characteristics of their stone disease with humans. The observed protein distributions were analyzed in the context of a recent model based on the aggregation of strongly anionic and strongly cationic proteins which includes selective adsorption of other proteins based on total charge. Matrix protein distributions shared many common features between species, including enrichment of both strongly anionic and strongly cationi

SUBMITTER: Wesson JA 

PROVIDER: S-EPMC10173728 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature