Molecular characterization of sub-frontal recurrent medulloblastomas reveals potential clinical relevance.

ABSTRACT:

Background

Single recurrence in the sub-frontal region after cerebellar medulloblastoma (MB) resection is rare and the underlying molecular characteristics have not been specifically addressed.

Methods

We summarized two such cases in our center. All five samples were molecularly profiled for their genome and transcriptome signatures.

Results

The recurrent tumors displayed genomic and transcriptomic divergence. Pathway analysis of recurrent tumors showed functional convergence in metabolism, cancer, neuroactive ligand-receptor interaction, and PI3K-AKT signaling pathways. Notably, the sub-frontal recurrent tumors had a much higher proportion (50-86%) of acquired driver mutations than that reported in other recurrent locations. The acquired putative driver genes in the

SUBMITTER: Chen Z 

PROVIDER: S-EPMC10173865 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature