Evaluating instrumental learning and striatal-cortical functional connectivity in adolescent alcohol and cannabis use.

ABSTRACT: Adolescence is a vulnerable time for the acquisition of substance use disorders, potentially relating to ongoing development of neural circuits supporting instrumental learning. Striatal-cortical circuits undergo dynamic changes during instrumental learning and are implicated in contemporary addiction theory. Human studies have not yet investigated these dynamic changes in relation to adolescent substance use. Here, functional magnetic resonance imaging was used while 135 adolescents without (AUD-CUD_Low ) and with significant alcohol (AUD_High ) or cannabis use disorder symptoms (CUD_High ) performed an instrumental learning task. We assessed how cumulative experience with instrumental cues altered cue selection preferences and functional connectivity strengt

SUBMITTER: Hubbard NA 

PROVIDER: S-EPMC10173870 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature