Response categorization and outcomes in extremely premature infants born at 22-26 weeks gestation that received inhaled nitric oxide for hypoxic respiratory failure.

ABSTRACT:

Objective

To evaluate the outcomes of extremely premature infants who received inhaled nitric oxide(iNO) for hypoxic respiratory failure(HRF).

Study design

Retrospective analysis of 107 infants born 22-26 weeks gestation who received iNO for HRF at a single institution. Infants were categorized as positive, negative, or no responders based on change in FiO₂ or OI. Underlying physiology was determined using Echocardiography/Radiography/Biochemistry.

Results

63% of infants had a positive response; they received iNO earlier and were more likely to have acute pulmonary hypertension(PH). Positive response correlated with decreased incidence of death or grade 3 BPD at 36 weeks postmenstrual age, as compared to a negative response.

Conclusions

Extremely pre

SUBMITTER: Boly TJ 

PROVIDER: S-EPMC10173872 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature