Predictive value of intratumoral-metabolic heterogeneity derived from ¹⁸F-FDG PET/CT in distinguishing microsatellite instability status of colorectal carcinoma.

ABSTRACT:

Purpose/background

Microsatellite instability (MSI) status is a significant biomarker for the response to immune checkpoint inhibitors, response to 5-fluorouracil-based adjuvant chemotherapy, and prognosis in colorectal carcinoma (CRC). This study investigated the predictive value of intratumoral-metabolic heterogeneity (IMH) and conventional metabolic parameters derived from ¹⁸F-FDG PET/CT for MSI in patients with stage I-III CRC.

Methods

This study was a retrospective analysis of 152 CRC patients with pathologically proven MSI who underwent ¹⁸F-FDG PET/CT examination from January 2016 to May 2022. Intratumoral-metabolic heterogeneity (including heterogeneity index [HI] and heterogeneity factor [HF]) and conventional metabolic parameters (standardized

SUBMITTER: Zhang L 

PROVIDER: S-EPMC10173881 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature