A drivable optrode for use in chronic electrophysiology and optogenetic experiments.

ABSTRACT:

Background

Combining optogenetic tools with behaving electrophysiology is a powerful approach for investigating the neural mechanisms underlying behavior. A traditional approach to ensure viable recordings during chronic long-term electrophysiological experiments is the use of drivable electrodes. However, few options exist for drivable optrodes.

New method

Here, we describe the design and construction of an economical drivable optrode for chronic experiments in behaving rodents, which allows for the simultaneous photo-stimulation and recording of distinct neuronal populations.

Results

We demonstrate the utility of the drivable optrode by recording light-evoked modulation in awake behaving rats over multiple recording sessions and across different depths. Using a viru

SUBMITTER: Stocke SK 

PROVIDER: S-EPMC10174211 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature