Toward therapeutic drug monitoring of citalopram in depression? Insights from a systematic review.

ABSTRACT:

Background

Within the framework of individualized psychopharmacotherapy, therapeutic drug monitoring (TDM) has gained increasing relevance. In the absence of high-quality evidence, the TDM of citalopram (CIT) and the recommended therapeutic ranges of the plasma concentrations have been proposed by guidelines. However, the correlation between the plasma concentration of CIT and treatment outcomes has not been well established. Therefore, the aim of this systematic review was to evaluate the relationship between plasma CIT concentration and treatment outcomes in depression.

Research design and methods

PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Chinese databases (CNKI, Wanfang Data and Sinomed) were searched up to August 6, 2022. We included c

SUBMITTER: Xu N 

PROVIDER: S-EPMC10174233 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature