Identification of VIPR2 rare and common variants in the Chinese Han population with schizophrenia.

ABSTRACT:

Introduction

Schizophrenia is a severe and chronic psychiatric disorder with hereditary risk up to 80% as previous studies indicated. Several researches have demonstrated a significant association between schizophrenia and microduplications that overlap the vasoactive intestinal peptide receptor 2 gene (VIPR2).

Methods

To further investigate potential causal VIPR2 gene variants, all exons and un-translated portions of the VIPR2 gene were sequenced using amplicon targeted resequencing in 1804 Chinese Han patients with schizophrenia and 996 healthy counterparts in the present study.

Results

Nineteen rare non-synonymous mutations and 1 frameshift deletion was identified for schizophrenia, among which 5 variants have never been reported so far. Freque

SUBMITTER: Yin J 

PROVIDER: S-EPMC10174236 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature