A method for capturing dynamic spectral coupling in resting fMRI reveals domain-specific patterns in schizophrenia.

ABSTRACT:

Introduction

Resting-state functional magnetic resonance imaging (rs-fMRI) is a powerful tool for assessing functional brain connectivity. Recent studies have focused on shorter-term connectivity and dynamics in the resting state. However, most of the prior work evaluates changes in time-series correlations. In this study, we propose a framework that focuses on time-resolved spectral coupling (assessed via the correlation between power spectra of the windowed time courses) among different brain circuits determined via independent component analysis (ICA).

Methods

Motivated by earlier work suggesting significant spectral differences in people with schizophrenia, we developed an approach to evaluate time-resolved spectral coupling (trSC). To do this, we first calculated the co

SUBMITTER: Alacam D 

PROVIDER: S-EPMC10174238 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature