Functional regionalization of the differentiating cerebellar Purkinje cell population occurs in an activity-dependent manner.

ABSTRACT:

Introduction

The cerebellum is organized into functional regions each dedicated to process different motor or sensory inputs for controlling different locomotor behaviors. This functional regionalization is prominent in the evolutionary conserved single-cell layered Purkinje cell (PC) population. Fragmented gene expression domains suggest a genetic organization of PC layer regionalization during cerebellum development. However, the establishment of such functionally specific domains during PC differentiation remained elusive.

Methods and results

We show the progressive emergence of functional regionalization of PCs from broad responses to spatially restricted regions in zebrafish by means of in vivo Ca2+-imaging during stereotypic locomotive behavior. Moreover, we reveal tha

SUBMITTER: Dorigo A 

PROVIDER: S-EPMC10174242 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature