Short exposure to photo-oxidative damage triggers molecular signals indicative of early retinal degeneration.

ABSTRACT:

Introduction

Age-related macular degeneration (AMD) is the leading cause of blindness in the developed world, currently affecting over 350 billion people globally. For the most prevalent late-stage form of this disease, atrophic AMD, there are no available prevention strategies or treatments, in part due to inherent difficulties in early-stage diagnosis. Photo-oxidative damage is a well-established model for studying inflammatory and cell death features that occur in late-stage atrophic AMD, however to date has not been investigated as a potential model for studying early features of disease onset. Therefore, in this study we aimed to determine if short exposure to photo-oxidative damage could be used to induce early retinal molecular changes and advance this as a potential model f

SUBMITTER: Wooff Y 

PROVIDER: S-EPMC10174249 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature