Anterior basolateral amygdala neurons comprise a remote fear memory engram.

ABSTRACT:

Introduction

Threatening environmental cues often generate enduring fear memories, but how these are formed and stored remains actively investigated. Recall of a recent fear memory is thought to reflect reactivation of neurons, in multiple brain regions, activated during memory formation, indicating that anatomically distributed and interconnected neuronal ensembles comprise fear memory engrams. The extent to which anatomically specific activation-reactivation engrams persist during long-term fear memory recall, however, remains largely unexplored. We hypothesized that principal neurons in the anterior basolateral amygdala (aBLA), which encode negative valence, acutely reactivate during remote fear memory recall to drive fear behavior.

Methods

Using adult offspring of TRAP2

SUBMITTER: Hammack RJ 

PROVIDER: S-EPMC10174320 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature