Genetic predisposition to subjective well-being, depression, and suicide in relation to COVID-19 susceptibility and severity.

ABSTRACT:

Background

Epidemiological studies have reported associations between subjective well-being (SWB), depression, and suicide with COVID-19 illness, but the causality has not been established. We performed a two-sample Mendelian randomization (MR) analysis to investigate the causal link between SWB, depression, suicide and COVID-19 susceptibility and severity.

Methods

Summary statistics for SWB (298,420 cases), depression (113,769 cases) and suicide (52,208 cases) were obtained from three large-scale GWAS. Data on the associations between the Single Nucleotide Polymorphisms (SNPs) and COVID-19 (159,840 cases), hospitalized COVID-19 (44,986 cases), and severe COVID-19 (18,152 cases) were collected from the COVID-19 host genetics initiative. The causal estimate was calculated by

SUBMITTER: Song H 

PROVIDER: S-EPMC10174343 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature