Study protocol for the epigenetic characterization of angor pectoris according to the affected coronary compartment: Global and comprehensive assessment of the relationship between invasive coronary physiology and microRNAs.

ABSTRACT:

Background

MicroRNAs (miRNAs) are noncoding RNAs involved in post-transcriptional genetic regulation with a proposed role in intercellular communication. miRNAs are considered promising biomarkers in ischemic heart disease. Invasive physiological evaluation allows a precise assessment of each affected coronary compartment. Although some studies have associated the expression of circulating miRNAs with invasive physiological indexes, their global relationship with coronary compartments has not been assessed. Here, we will evaluate circulating miRNAs profiles according to the coronary pattern of the vascular compartment affectation.

Study and design

This is an investigator-initiated, multicentre, descriptive study to be conducted at three centres in Spain (NCT05374694). The st

SUBMITTER: Matute-Blanco L 

PROVIDER: S-EPMC10174526 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature