Gut microbiota interspecies interactions shape the response of Clostridioides difficile to clinically relevant antibiotics.

ABSTRACT: In the human gut, the growth of the pathogen Clostridioides difficile is impacted by a complex web of interspecies interactions with members of human gut microbiota. We investigate the contribution of interspecies interactions on the antibiotic response of C. difficile to clinically relevant antibiotics using bottom-up assembly of human gut communities. We identify 2 classes of microbial interactions that alter C. difficile's antibiotic susceptibility: interactions resulting in increased ability of C. difficile to grow at high antibiotic concentrations (rare) and interactions resulting in C. difficile growth enhancement at low antibiotic concentrations (common). Based on genome-wide transcriptional profiling data, we demonstrate that metal sequestration due to hydrogen sulfide production b

SUBMITTER: Hromada S 

PROVIDER: S-EPMC10174544 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature