Pan-genome survey of the fish pathogen Yersinia ruckeri links accessory- and amplified genes to virulence.

ABSTRACT: While both virulent and putatively avirulent Yersinia ruckeri strains exist in aquaculture environments, the relationship between the distribution of virulence-associated factors and de facto pathogenicity in fish remains poorly understood. Pan-genome analysis of 18 complete genomes, representing established virulent and putatively avirulent lineages of Y. ruckeri, revealed the presence of a number of accessory genetic determinants. Further investigation of 68 draft genome assemblies revealed that the distribution of certain putative virulence factors correlated well with virulence and host-specificity. The inverse-autotransporter invasin locus yrIlm was, however, the only gene present in all virulent strains, while absent in lineages regarded as avirulent. Strains known to be associated w

SUBMITTER: Riborg A 

PROVIDER: S-EPMC10174560 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature