Neutrophil interactions with T cells, platelets, endothelial cells, and of course tumor cells.

ABSTRACT: Neutrophils sense microbes and host inflammatory mediators, and traffic to sites of infection where they direct a broad armamentarium of antimicrobial products against pathogens. Neutrophils are also activated by damage-associated molecular patterns (DAMPs), which are products of cellular injury that stimulate the innate immune system through pathways that are similar to those activated by microbes. Neutrophils and platelets become activated by injury, and cluster and cross-signal to each other with the cumulative effect of driving antimicrobial defense and hemostasis. In addition, neutrophil extracellular traps are extracellular chromatin and granular constituents that are generated in response to microbial and damage motifs and are pro-thrombotic and injurious. Although neutrophils can w

SUBMITTER: Segal BH 

PROVIDER: S-EPMC10174640 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature