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Single-cell transcriptomics of a dynamic cell behavior in murine airways.

ABSTRACT: Despite advances in high-dimensional cellular analysis, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method that allows us to couple the physiological behaviors of cells in an intact murine tissue to deep molecular profiling of individual cells. This method enabled us to establish a novel molecular signature for a striking migratory cellular behavior following injury in murine airways.

SUBMITTER: Kwok SJJ

PROVIDER: S-EPMC10174686 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature

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Single-cell transcriptomics of a dynamic cell behavior in murine airways.

Kwok Sheldon J J SJJ Montoro Daniel T DT Haber Adam L AL Yun Seok-Hyun SH Vinarsky Vladimir V

eLife 20230421

Despite advances in high-dimensional cellular analysis, the molecular profiling of dynamic behaviors of cells in their native environment remains a major challenge. We present a method that allows us to couple the physiological behaviors of cells in an intact murine tissue to deep molecular profiling of individual cells. This method enabled us to establish a novel molecular signature for a striking migratory cellular behavior following injury in murine airways. ...[more]

PMID: 37083555

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