Ferula sinkiangensis against gastric cancer: a network pharmacology, molecular docking and cell experiment study.

ABSTRACT:

Background

Ferula sinkiangensis (F. sinkiangensis) is a traditional Chinese medicine that has been used for thousands of years to treat stomach ailments. To identify the main active compounds and explore the mechanisms underlying the therapeutic effect of F. sinkiangensis against gastric cancer (GC) by network pharmacology, molecular docking analysis and cell experiment.

Methods

Based on a review of the literature and previous experiments conducted by our research group, the active compounds of F. sinkiangensis were obtained. Active compounds and their target genes were screened from SwissADME, Pubchem, and Pharmmapper databases. GC-related target genes were obtained from GeneCards. The drug-compound-target-disease (D-C-T-D) network and protein-pr

SUBMITTER: Wang D 

PROVIDER: S-EPMC10174895 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature