N⁶-methyladenosine reader IGF2BP3 as a prognostic Biomarker contribute to malignant progression of glioma.

ABSTRACT:

Background

Glioblastoma (GBM) is a highly aggressive cancer having a dismal prognosis. N⁶-methyladenosine (m⁶A) is closely related to GBM progression. The significance of m⁶A modifications depends on the m⁶A readers, whose functions in glioma progression are largely unknown. This study sought to investigate the expression of the m⁶A related gene in glioma and its effect on the malignant progression of glioma.

Methods

The expression differences between low-grade gliomas (LGGs) and high-grade gliomas (HGGs), and among 19 m6A-related genes were analyzed by The Cancer Genome Atlas (TCGA). Survival probability was analyzed in terms of the high or low expression of insulin growth factor-2 binding protein 3 (IGF2BP3) in

SUBMITTER: Zheng X 

PROVIDER: S-EPMC10174994 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature