Targeted therapies in advanced biliary tract cancers-a narrative review.

ABSTRACT:

Background and objective

Biliary tract cancers (BTCs), including cholangiocarcinoma and gallbladder cancer, are a relatively rare group of cancers with a poor prognosis. Over the past decade, the utilization of next-generation sequencing has led to the identification of multiple actionable somatic aberrations in BTCs. Subsequently, new therapies have been created to target these molecular alterations and have been incorporated into clinical practice. In this review, we outline therapies that have been previously studied, and those that are under investigation, to target genomic alterations with the goal of improving survival in patients with advanced disease.

Methods

A literature search was performed to identify phase I, II, and III trials of targeted therapies in patients w

SUBMITTER: LaPelusa M 

PROVIDER: S-EPMC10175163 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature