ARSK1 activates TORC1 signaling to adjust growth to phosphate availability in Arabidopsis.

ABSTRACT: Nutrient sensing and signaling are essential for adjusting growth and development to available resources. Deprivation of the essential mineral phosphorus (P) inhibits root growth.¹ The molecular processes that sense P limitation to trigger early root growth inhibition are not known yet. Target of rapamycin (TOR) kinase is a central regulatory hub in eukaryotes to adapt growth to internal and external nutritional cues.^2,3 How nutritional signals are transduced to TOR to control plant growth remains unclear. Here, we identify Arabidopsis-root-specific kinase 1 (ARSK1), which attenuates initial root growth inhibition in response to P limitation. We demonstrate that ARSK1 phosphorylates and stabilizes the regulatory-associated protein of TOR 1B (RAPT

SUBMITTER: Cho H 

PROVIDER: S-EPMC10175222 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature