Mitofusin 2 Sustains the Axonal Mitochondrial Network to Support Presynaptic Ca²⁺ Homeostasis and the Synaptic Vesicle Cycle in Rat Hippocampal Axons.

ABSTRACT: Mitochondria exert powerful control over cellular physiology, contributing to ion homeostasis, energy production, and metabolite biosynthesis. The trafficking and function of these organelles are particularly important in neurons, with impaired mitochondrial function or altered morphology observed in every neurodegenerative disorder studied. While mitochondrial biosynthetic products play a crucial role in maintaining cellular function, their resulting byproducts can have negative consequences. Thus, organelle quality control (QC) mechanisms that maintain mitochondrial function are imperative to restrict destructive signaling cascades in the cell. Axons are particularly sensitive to damage, and there is little consensus regarding the mechanisms that mediate mitochondrial QC in this compartm

SUBMITTER: Vevea JD 

PROVIDER: S-EPMC10175236 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature