Plasma Exosome Gene Signature Differentiates Colon Cancer from Healthy Controls.

ABSTRACT:

Background

Liquid biopsies have become an integral part of cancer management as minimally invasive options to detect molecular and genetic changes. However, current options show poor sensitivity in peritoneal carcinomatosis (PC). Novel exosome-based liquid biopsies may provide critical information on these challenging tumors. In this initial feasibility analysis, we identified an exosome gene signature of 445 genes (ExoSig445) from colon cancer patients, including those with PC, that is distinct from healthy controls.

Methods

Plasma exosomes from 42 patients with metastatic and non-metastatic colon cancer and 10 healthy controls were isolated and verified. RNAseq analysis of exosomal RNA was performed and differentially expressed genes (DEGs) were identified by the DESeq2 al

SUBMITTER: Vallejos PA 

PROVIDER: S-EPMC10175396 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature