Mechanical deformation of elastomer medical devices can enable microbial surface colonization.

ABSTRACT: Elastomers such as silicone are common in medical devices (catheters, prosthetic implants, endoscopes), but they remain prone to microbial colonization and biofilm infections. For the first time, our work shows that rates of microbial surface attachment to polydimethylsiloxane (PDMS) silicone can be significantly affected by mechanical deformation. For a section of bent commercial catheter tubing, bacteria (P. aeruginosa) show a strong preference for the 'convex' side compared to the 'concave' side, by a factor of 4.2. Further testing of cast PDMS materials in bending only showed a significant difference for samples that were manually wiped (damaged) beforehand (1.75 × 10⁴ and 6.02 × 10³ cells/mm² on the convex and concave sides, respectively). We demonstra

SUBMITTER: van den Berg D 

PROVIDER: S-EPMC10175502 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature