BLM helicase overexpressed in human gliomas contributes to diverse responses of human glioma cells to chemotherapy.

ABSTRACT: Most of anti-tumour therapies eliminate neoplastic cells by introducing DNA damage which ultimately triggers cell death. These effects are counteracted by activated DNA repair pathways to sustain tumour proliferation capacity. RECQL helicases family, including BLM, participate in DNA damage and repair, and prevent the replication stress. Glioblastoma (GBM) is a common, malignant brain tumour that inevitably recurs despite surgical resection, radiotherapy, and chemotherapy with temozolomide (TMZ). Expression and functions of the BLM helicase in GBM therapy resistance have not been elucidated. We analysed expression and localisation of BLM in human gliomas and several glioma cell lines using TCGA datasets, immunostaining and Western blotting. BLM depleted human glioma cells were generated wi

SUBMITTER: Wojnicki K 

PROVIDER: S-EPMC10175545 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature