Distinct histopathological features are associated with molecular subtypes and outcome in low grade serous ovarian carcinoma.

ABSTRACT: Low grade serous ovarian carcinoma (LGSOC) demonstrates unique clinical and molecular features compared to other ovarian cancer types. The relationship between common histological features of LGSOC and molecular events, such as hormone receptor expression patterns and MAPK gene mutation status, remains poorly understood. Recent data suggest some of these molecular features may be biomarkers of response to recently introduced biologically-targeted therapies, namely endocrine therapy and MEK inhibitors. We utilize a cohort of 63 pathologically-confirmed LGSOC cases with whole exome sequencing and hormone receptor expression data to investigate these relationships. LGSOC cases demonstrated uniformly high oestrogen receptor (ER) expression, but variable progesterone receptor (PR) expression in

SUBMITTER: Hollis RL 

PROVIDER: S-EPMC10175560 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature