Low Diversity of Major Histocompatibility Complex (MHC) Genes in Endangered Malayan Tapir (Tapirus indicus).

ABSTRACT: The Malayan tapir (Tapirus indicus) is listed as Endangered on the IUCN Red List due to multiple threats such as habitat loss and human disturbance that have led to its population decline. This decline increases the risk of inbreeding, which could result in the reduction of genome-wide genetic variation and negatively affect the gene responsible for immune response i.e., MHC gene. Class I and II MHC genes are responsible for encoding MHC molecules in the cells that recognise pathogenic peptides and present them to T-Cells on the cell surface for adaptive immune response. However, at present there is no study related to the MHC gene in Malayan tapir yet. This study characterises the MHC class I and II genes from seven individuals, investigates evidence of balancing selection a

SUBMITTER: Ismail NA 

PROVIDER: S-EPMC10175568 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature