Striatal spatial heterogeneity, clustering, and white matter association of GFAP⁺ astrocytes in a mouse model of Huntington's disease.

ABSTRACT:

Introduction

Huntington's disease (HD) is a neurodegenerative disease that primarily affects the striatum, a brain region that controls movement and some forms of cognition. Neuronal dysfunction and loss in HD is accompanied by increased astrocyte density and astrocyte pathology. Astrocytes are a heterogeneous population classified into multiple subtypes depending on the expression of different gene markers. Studying whether mutant Huntingtin (HTT) alters specific subtypes of astrocytes is necessary to understand their relative contribution to HD.

Methods

Here, we studied whether astrocytes expressing two different markers; glial fibrillary acidic protein (GFAP), associated with astrocyte activation, and S100 calcium-binding protein B (S100B), a marker of matured astrocytes

SUBMITTER: Brown TG 

PROVIDER: S-EPMC10175581 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature