Serotonin/GABA receptors modulate odor input to olfactory receptor neuron in locusts.

ABSTRACT:

Introduction

Serotonin (5-hydroxytryptamine; 5-HT) and GABA (γ-aminobutyric acid) are involved in the regulation of behaviors in the central nervous system. However, it remains unclear whether they modulate olfaction in the peripheral nervous system, and how they modulate olfaction.

Methods and results

One 5-HT receptor sequence (Lmig5-HT2) and one GABA receptor sequence (LmigGABAb) were identified in locust antennae by transcriptome analysis and polymerase chain reaction experiments. In situ hybridization localized Lmig5-HT2 to accessory cells, while LmigGABAb was localized to olfactory receptor neurons (ORNs) in locust chemosensilla. Single-unit electrophysiological recordings combined with RNA interference (RNAi) experiments indicated OR

SUBMITTER: Lv M 

PROVIDER: S-EPMC10175586 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature