Low-dose vs. standard-dose intravenous alteplase for acute ischemic stroke with unknown time of onset.

ABSTRACT:

Background

Standard-dose intravenous alteplase for acute ischemic stroke (AIS) in the unknown or extended time window beyond 4.5 h after symptom onset is both effective and safe for certain patients who were selected based on multimodal neuroimaging. However, uncertainty exists regarding the potential benefit of using low-dose alteplase among the Asian population outside the 4.5-h time window.

Methods

Consecutive AIS patients who received intravenous alteplase between 4.5 and 9 h after symptom onset or with an unknown time of onset guided by multimodal computed tomography (CT) imaging were identified from our prospectively maintained database. The primary outcome was excellent functional recovery, defined as having a modified Rankin scale (mRS) score of 0-1 at 90 days. Secon

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10175638 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature