Rheumatoid arthritis and coronary atherosclerosis: a two-sample Mendelian randomization study.

ABSTRACT:

Objectives

The relationship between rheumatoid arthritis (RA) and coronary atherosclerosis is widely concerned, but observational studies have not clarified causality. We performed two-sample Mendelian randomization (MR) study to assess the causal association between RA and coronary atherosclerosis.

Methods

we mainly conducted MR analysis using the inverse variance weighted (IVW) approach. Weighted median, MR-Egger regression and maximum likelihood were conducted as sensitivity analyses for supplementary analysis. Multivariate MR also were performed to validate the results of two-sample MR. Furthermore, we performed the MR-Egger intercept, MR-PRESSO, Cochran's Q test, and "Leave-one-out" to assess the levels of pleiotropy and heterogeneity.

Results

IVW result showed a

SUBMITTER: Nie Q 

PROVIDER: S-EPMC10175685 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature