Population pharmacokinetic analysis and dosing regimen optimization of teicoplanin in critically ill patients with sepsis.

ABSTRACT: Objectives: Teicoplanin has been extensively used in the treatment for infections caused by gram-positive bacteria including methicillin-resistant Staphylococcus aureus (MRSA). However, current teicoplanin treatment is challenging due to relatively low and variable concentrations under standard dosage regimens. This study aimed to investigate the population pharmacokinetics (PPK) characteristics of teicoplanin in adult sepsis patients and provide recommendations for optimal teicoplanin dosing regimens. Methods: A total of 249 serum concentration samples from 59 septic patients were prospectively collected in the intensive care unit (ICU). Teicoplanin concentrations were detected, and patients' clinical data were recorded. PPK analysis was performed using a non-linear,

SUBMITTER: Chen CY 

PROVIDER: S-EPMC10175687 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature