Carboplatin Induction Chemotherapy in Clinically Lymph Node-positive Bladder Cancer.

ABSTRACT:

Background

There are currently no guideline recommendations regarding the treatment of cisplatin-ineligible, clinically lymph node-positive (cN+) bladder cancer (BCa).

Objective

To investigate the oncological efficacy of gemcitabine/carboplatin induction chemotherapy (IC) in comparison to cisplatin-based regimens in cN+ BCa.

Design setting and participants

This was an observational study of 369 patients with cT2-4 N1-3 M0 BCa.

Intervention

IC followed by consolidative radical cystectomy (RC).

Outcome measurements and statistical analysis

The primary endpoints were the pathological objective response (pOR; ypT0/Ta/Tis/T1 N0) rate and the pathological complete response (pCR; ypT0N0) rate. We applied 3:1 propensity score matching (PSM) to reduce selection b

SUBMITTER: von Deimling M 

PROVIDER: S-EPMC10175724 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature