A morphine reward generalization mouse model based on conditioned place preference and aversion.

ABSTRACT:

Background

Conditioned place preference (CPP) is a common behavioral paradigm for studying the association of unconditioned stimulus reward memory with context. Generalization is a flexible memory recall pattern developed on the basis of original memory. Drug-seeking behaviors in substance use disorders (SUDs) exhibit diversity, which we generally attribute to the highly generalized features of SUD memory. However, to date, there are no animal models for SUD generalization studies.

Methods

We design the generalization box (G-box) and the generalization retrieval process based on the conditioned place preference (CPP) model. In the memory retrieval stage, we replaced the conditioning CPP box (T-box) with a generalization box (G-box) to study drug generalization memory. For ap

SUBMITTER: Hou XF 

PROVIDER: S-EPMC10175973 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature