Females present higher dose-adjusted drug concentrations of metoprolol and allopurinol/oxypurinol than males.

ABSTRACT: Females present a higher risk of adverse drug reactions. Sex-related differences in drug concentrations may contribute to these observations but they remain understudied given the underrepresentation of females in clinical trials. The aim of this study was to investigate whether anthropometric and socioeconomic factors and comorbidities could explain sex-related differences in concentrations and dosing for metoprolol and oxypurinol, the active metabolite of allopurinol. We conducted an analysis of two cross-sectional studies. Participants were self-described "White" adults taking metoprolol or allopurinol selected from the Montreal Heart Institute Hospital Cohort. A total of 1007 participants were included in the metoprolol subpopulation and 459 participants in the allopurinol subpopulatio

SUBMITTER: Hindi J 

PROVIDER: S-EPMC10175982 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature