Heritability of human "directed" functional connectome.

ABSTRACT:

Introduction

The functional connectivity patterns in the brain are highly heritable; however, it is unclear how genetic factors influence the directionality of such "information flows." Studying the "directionality" of the brain functional connectivity and assessing how heritability modulates it can improve our understanding of the human connectome.

Methods

Here, we investigated the heritability of "directed" functional connections using a state-space formulation of Granger causality (GC), in conjunction with blind deconvolution methods accounting for local variability in the hemodynamic response function. Such GC implementation is ideal to explore the directionality of functional interactions across a large number of networks. Resting-state functional magnetic resonance ima

SUBMITTER: Bianco MG 

PROVIDER: S-EPMC10175995 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature