Factors influencing the presence of potentially explosive gases during colonoscopy: Results of the SATISFACTION study.

ABSTRACT: This study tested the hypothesis that bowel preparation with mannitol should not affect the colonic concentration of H₂ and CH₄ . Therefore, the SATISFACTION study, an international, multicenter, randomized, parallel-group phase II-III study investigated this issue. The phase II dose-finding part of the study evaluated H₂ , CH₄ , and O₂ concentrations in 179 patients randomized to treatment with 50 g, 100 g, or 150 g mannitol. Phase III of the study compared the presence of intestinal gases in 680 patients randomized (1:1) to receive mannitol 100 g in single dose or a standard split-dose 2 L polyethylene glycol (PEG)-Asc preparation (2 L PEG-Asc). Phase II results showed that mannitol did not influence the concentration of intestinal g

SUBMITTER: Carnovali M 

PROVIDER: S-EPMC10176010 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature