The heterogeneity of asymmetric tau distribution is associated with an early age at onset and poor prognosis in Alzheimer's disease.

ABSTRACT:

Purpose

Left-right asymmetry, an important feature of brain development, has been implicated in neurodegenerative diseases, although it's less discussed in typical Alzheimer's disease (AD). We sought to investigate whether asymmetric tau deposition plays a potential role in AD heterogeneity.

Methods

Two independent cohorts consisting of patients with mild cognitive impairment due to AD and AD dementia with tau PET imaging were enrolled [the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort with ¹⁸F-Flortaucipir, the Shanghai Memory Study (SMS) cohort with ¹⁸F-Florzolotau]. Based on the absolute global tau interhemispheric differences, each cohort was divided into two groups (asymmetric versus symmetric tau distribution). The two groups were cros

SUBMITTER: Lu J 

PROVIDER: S-EPMC10176076 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature