Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cells.

ABSTRACT: Transposable elements constitute a substantial portion of most eukaryotic genomes and their activity can lead to developmental and neuronal defects. In the germline, transposon activity is antagonized by the PIWI-interacting RNA pathway tasked with repression of transposon transcription and degrading transcripts that have already been produced. However, most of the genes required for transposon control are not expressed outside the germline, prompting the question: what causes deleterious transposons activity in the soma and how is it managed? Here, we show that disruptions of the Histone 3 lysine 36 methylation machinery led to increased transposon transcription in Drosophila melanogaster brains and that there is division of labour for the repression of transposable elements betwee

SUBMITTER: Lindehell H 

PROVIDER: S-EPMC10176111 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature