The serum proteome of VA-ECMO patients changes over time and allows differentiation of survivors and non-survivors: an observational study.

ABSTRACT:

Background

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is applied in patients with refractory hemodynamic failure. Exposure of blood components to high shear stress and the large extracorporeal surfaces in the ECMO circuit trigger a complex inflammatory response syndrome and coagulopathy which are believed to worsen the already poor prognosis of these patients. Mass spectrometry-based proteomics allow a detailed characterization of the serum proteome as it provides the identity and concentration of large numbers of individual proteins at the same time. In this study, we aimed to characterize the serum proteome of patients receiving VA-ECMO.

Methods

Serum samples were collected on day 1 and day 3 after initiation of VA-ECMO. Samples underwent immunoaffinity ba

SUBMITTER: Siegel PM 

PROVIDER: S-EPMC10176307 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature