Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease.

ABSTRACT:

Rationale

Eosinophils are associated with airway inflammation in respiratory disease. Eosinophil production and survival is controlled partly by interleukin-5: anti-interleukin-5 agents reduce asthma and response correlates with baseline eosinophil counts. However, whether raised eosinophils are causally related to chronic obstructive pulmonary disease (COPD) and other respiratory phenotypes is not well understood.

Objectives

We investigated causality between eosinophils and: lung function, acute exacerbations of COPD, asthma-COPD overlap (ACO), moderate-to-severe asthma and respiratory infections.

Methods

We performed Mendelian randomisation (MR) using 151 variants from genome-wide association studies of blood eosinophils in UK Biobank/INTERVAL, and respiratory trait

SUBMITTER: Guyatt A 

PROVIDER: S-EPMC10176352 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature