Analysis of cervical HPV infections among unvaccinated young adult women to inform vaccine strategies in this age group: the Costa Rica HPV Vaccine Trial.

ABSTRACT:

Introduction

Human papillomavirus (HPV) vaccines protect against incident HPV infections, which cause cervical cancer.

Objectives

We estimated the prevalence and incidence of HPV infections in young adult women to understand the impact of an HPV vaccination programme in this population.

Methods

We collected cervical specimens from 6322 unvaccinated women, aged 18-37 years, who participated in the Costa Rica Vaccine Trial and its long-term follow-up. Women were followed for (median) 4.8 years and had (median) 4.0 study visits. Cervical specimens were tested for the presence/absence of 25 HPV genotypes. For each age band, we estimated the percentage of women with 1+ prevalent or 1+ incident HPV infections using generalised estimating equations. We also estimated the pre

SUBMITTER: Sierra MS 

PROVIDER: S-EPMC10176398 | biostudies-literature | 2022 Jul

REPOSITORIES: biostudies-literature