Serum metabolomic profiles in BALB/c mice induced by Babesia microti infection.

ABSTRACT:

Introduction

The protozoan parasite Babesia microti is the primary cause of human babesiosis. This parasite invades and multiplies inside red blood cells (RBCs), and infections differ significantly based on the age and immune competency of the host. The aim of this study was to investigate the use of serum metabolic profiling to identify systemic metabolic variations between B. microti-infected mice and noninfected controls.

Methods

A serum metabolomics analysis of BALB/c mice that had been intraperitoneally injected with 10⁷ B. microti-infected RBCs was performed. Serum samples from the early infected group (2 days postinfection), the acutely infected group (9 days postinfection), and the noninfected group were collected and evaluated using a

SUBMITTER: Shen L 

PROVIDER: S-EPMC10176453 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature