Multiple sclerosis, disease-modifying drugs and risk for adverse perinatal and pregnancy outcomes: Results from a population-based cohort study.

ABSTRACT:

Background

There is a paucity of information on maternal multiple sclerosis (MS) and risk of adverse pregnancy and perinatal outcomes.

Objective

The aim of this study was to determine the association between MS and risks of adverse pregnancy and perinatal outcomes in women with MS. In women with MS, the influence of exposure to disease-modifying therapy (DMT) was also investigated.

Methods

Population-based retrospective cohort study on singleton births to mothers with MS and matched MS-free mothers from the general population in Sweden between 2006 and 2020. Women with MS were identified through Swedish health care registries, with MS onset before child's birth.

Results

Of 29,568 births included, 3418 births were to 2310 mothers with MS. Compared with MS-free c

SUBMITTER: Fink K 

PROVIDER: S-EPMC10176621 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature