Gut microbiome combined with metabolomics reveals biomarkers and pathways in central precocious puberty.

ABSTRACT:

Background

Central precocious puberty (CPP) is a common disease in prepubertal children and results mainly from disorders in the endocrine system. Emerging evidence has highlighted the involvement of gut microbes in hormone secretion, but their roles and downstream metabolic pathways in CPP remain unknown.

Methods

To explore the gut microbes and metabolism alterations in CPP, we performed the 16S rRNA sequencing and untargeted metabolomics profiling for 91 CPP patients and 59 healthy controls. Bioinformatics and statistical analyses, including the comparisons of alpha and beta diversity, abundances of microbes, were undertaken on the 16S rRNA gene sequences and metabolism profiling. Classifiers were constructed based on the microorganisms and metabolites. Functional and path

SUBMITTER: Huang X 

PROVIDER: S-EPMC10176710 | biostudies-literature | 2023 May

REPOSITORIES: biostudies-literature